COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome

Authors

  • Rozhin Amin Community Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Social Determinants of Health Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mohammad-Reza Sohrabi Community Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Social Determinants of Health Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-6811-3955
  • Ali-Reza Zali Functional Neurosurgery Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Khatereh Hannani Statistics and Information Technology Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.17305/bb.2023.9748

Keywords:

Coronavirus disease 2019 (COVID-19), disease severity, Iran, pandemics, pregnant women, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Abstract

Assessing the impact of coronavirus disease 2019 (COVID-19) reveals unique challenges for pregnant women, who experience distinct clinical manifestations and health outcomes compared to their non-pregnant counterparts. We aimed to evaluate the clinical features, disease severity, and health outcomes of COVID-19 in pregnant women and compare them to those of non pregnant women. In this population-based study, we included all women diagnosed with COVID-19 across the province of Tehran during the first two years of the epidemic. Descriptive statistics, the chi-squared test, and the logistic regression model were applied. Overall, 79,338 non-pregnant women and 3249 pregnant women diagnosed with COVID-19 were included. Pregnant women were most commonly in the age group of 25 – 34 years (54%, n = 1758), while the age group of 34–44 had the highest representation among non-pregnant women (56%, n = 44,492). After accounting for age and comorbidities, pregnancy was associated with an increased risk of requiring intensive care (odds ratio [OR] 1.38, confidence interval [CI] 1.223 – 1.564). However, the probability of dying due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was lower in pregnant women compared to non-pregnant women (OR 0.55, CI 0.394–0.793). Cough (41%) and fever (30%) were the most frequent clinical presentations in pregnant women, whereas cough (57%) and muscle ache (38%) were the most common symptoms in non-pregnant women. Furthermore, diarrhea (P < 0.001) and skin lesions (P < 0.001) were reported more frequently by pregnant patients than non-pregnant patients. A significant prevalence of diabetes (P < 0.001), hypertension (P < 0.001), cancers (P < 0.001), and chronic hematological diseases (P < 0.001) was observed in pregnant patients. In conclusion, COVID-19-infected pregnant women exhibit different clinical manifestations and a more severe clinical course but have better health outcomes compared to their non-pregnant counterparts.

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COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome

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Published

02-05-2024

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New and Emerging Medical Entities

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How to Cite

1.
COVID-19 in pregnancy: A cross-sectional study on clinical features, disease severity, and health outcome. Biomol Biomed [Internet]. 2024 May 2 [cited 2024 May 20];24(3):659–664. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/9748