Epidemiology, pathogenicity, risk factors, and management of Helicobacter pylori infection in Saudi Arabia

Authors

  • Mutasim E. Ibrahim Department of Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, Saudi Arabia

DOI:

https://doi.org/10.17305/bb.2023.9575

Keywords:

Helicobacter pylori, prevalence, pathogenicity, gastric cancer, risk factors, management, Saudi Arabia

Abstract

Helicobacter pylori (H. pylori) is a gastric microbial pathogen that infects approximately half of the global population. This bacterium significantly contributes to various gastroduodenal diseases, including chronic active gastritis, peptic ulcerations, and malignant transformations. This review focuses on epidemiology, pathogenicity, virulence genes, risk factors, and management of H. pylori infection, specifically within the context of Saudi Arabia. The results presented here are grounded in studies conducted in Saudi Arabia, contrasting with mere bibliographic reviews of findings from other countries. H. pylori infection has been observed in Saudi Arabia, with substantial differences in the prevalence, ranging between 10-96% among various studied populations. Several risk factors for H. pylori infection have been identified, encompassing socioeconomic status, medical history, personal hygiene, and behavioral practices. Among the virulence genes harbored by H. pylori, cytotoxin-associated gene A (cagA) and vacuolating cytotoxin (vacA) are most common, with their presence correlating with the pathogenicity and clinical manifestations of the associated diseases. A range of invasive and non-invasive diagnostic assays have been utilized to identify H. pylori infection, with their employment being influenced by factors like availability, cost, patient age, gastric symptoms, and the specifics of clinical information sought. While detection methods like the H. pylori stool antigen test and the urea breath test offer more accuracy and speed, culturing remains indispensable for determining the antimicrobial susceptibility profile. The emergence of resistant strains across varying regional settings poses a significant challenge to treatment endeavors, necessitating an assessment of local antimicrobial resistance rates prior to formulating treatment strategies. The findings of this review highlight the importance of continuous implementation of screening, control, and prevention of H. pylori infection to combat the spreading infection and other related complications.

Downloads

Download data is not yet available.
 Epidemiology, pathogenicity, risk factors, and management of Helicobacter pylori infection in Saudi Arabia

Downloads

Published

02-05-2024

Issue

Section

Reviews

Categories

How to Cite

1.
Epidemiology, pathogenicity, risk factors, and management of Helicobacter pylori infection in Saudi Arabia. Biomol Biomed [Internet]. 2024 May 2 [cited 2024 May 20];24(3):440–453. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/9575