Remifentanil-induced preconditioning has cross-talk with A1 and A2B adenosine receptors in ischemic-reperfused rat heart

Yong-Cheol Lee; Jiyoon Jung; Sang-Jin Park

doi:10.17305/bjbms.2016.738

Authors

Yong-Cheol Lee Department of Anesthesiology and Pain Medicine, School of Medicine, Keimyung University
Jiyoon Jung Department of Anesthesiology and Pain Medicine, College of Medicine, Yeungnam University
Sang-Jin Park Department of Anesthesiology and Pain Medicine, College of Medicine, Yeungnam University

DOI:

https://doi.org/10.17305/bjbms.2016.738

Keywords:

Adenosine, Cross-talk, Remifentanil, Reperfusion, Preconditioning

Abstract

The purpose of this study was to determine whether there is a cross-talk between opioid receptors (OPRs) and adenosine receptors (ADRs) in remifentanil preconditioning (R-Pre) and, if so, to investigate the types of ADRs involved in the cross-talk. Isolated rat hearts received 30 min of regional ischemia followed by 2 hr of reperfusion. OPR and ADR antagonists were perfused from 10 min before R-Pre until the end of R-Pre. The heart rate, left ventricular developed pressure (LVDP),velocity of contraction (+dP/dt_max), and coronary flow (CF) were recorded. The area at risk and area of necrosis were measured. After reperfusion, the LVDP, +dP/dt_max,and CF showed a significant increase in the R-Pre group compared with the control group (no intervention before or after regional ischemia). These increases in the R-Pre group were blocked by naloxone, a nonspecific ADR antagonist, an A₁ADR antagonist, and an A_2BADR antagonist. The infarct size was reduced significantly in the R-Pre group compared with the control group. The infarct-reducing effect in the R-Pre group was blocked by naloxone, the nonspecific ADR antagonist, the A₁ADR antagonist, and the A_2BADR antagonist. The results of this study demonstrate that there is cross-talk between ADRs and OPRs in R-Pre and that A₁ADR and A_2BADR appear to be involved in the cross-talk.

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