Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention

Authors

  • Alejandra Rocío Pérez-Martín Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0002-3681-5178
  • Denisse Castro-Eguiluz Investigador por México CONACYT-Department of Clinical Research, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0001-6873-122X
  • Lucely Cetina-Pérez Department of Clinical Research and Medical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0003-2018-7338
  • Yadira Velasco-Torres Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0003-2731-8150
  • Antonio Bahena-González Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico; Department of Medical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
  • Edgar Montes-Servín Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0003-3746-6739
  • Ernesto González-Ibarra Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0002-6326-3663
  • Raquel Espinosa-Romero Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico; Department of Medical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0002-4488-638X
  • Dolores Gallardo-Rincón Ovarian and Endometrial Cancer Program (COE), Instituto Nacional de Cancerología (INCan), Mexico City, Mexico; Department of Medical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico https://orcid.org/0000-0002-0628-8290

DOI:

https://doi.org/10.17305/bjbms.2021.6963

Keywords:

Metabolic syndrome, endometrial cancer, obesity, diet, prevention strategies

Abstract

Endometrial cancer is the second gynecological cancer with the highest global incidence. Among many associated risk factors, metabolic syndrome is an important and preventable one. It comprises a group of conditions that often occur together: central adiposity, hyperglycemia, arterial hypertension, and atherogenic dyslipidemia. This review aimed to describe the epidemiological and biological relationship between metabolic syndrome and endometrial cancer, focusing on the role of lifestyle in prevention. A literature search was carried out in the PubMed database. 4824 publications were screened, and 123 were included for this review. The association between metabolic syndrome and endometrial cancer has been described. Chronic adipose tissue inflammation and insulin resistance are involved in the development of obesity, particularly visceral adiposity. These changes promote the ideal environment for the development of endometrial cancer. Strategies based on lifestyle modifications may be effective for the prevention of metabolic syndrome and consequently endometrial cancer. Some of these modifications include adopting a diet rich in fruits, vegetables, whole grains, and legumes, depending to the accessibility of these foods for each region. Avoiding ultra-processed foods and increasing daily physical activity were also some suggested modifications. We propose that women be screened for metabolic syndrome to establish early treatment and to possibly prevent endometrial cancer. Clinical trials designed to prove the effect of lifestyle modifications on the prevention of endometrial cancer are needed.

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Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention

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Published

2022-02-27

How to Cite

1.
Pérez-Martín AR, Castro-Eguiluz D, Cetina-Pérez L, Velasco-Torres Y, Bahena-González A, Montes-Servín E, González-Ibarra E, Espinosa-Romero R, Gallardo-Rincón D. Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention. Bosn J of Basic Med Sci [Internet]. 2022Feb.27 [cited 2022Jul.4];. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/6963

Issue

Section

Reviews