Application of microfluidic chips in anticancer drug screening

Xin-yue  Fan; Zhuo-fen  Deng; Yan-yan  Yan; Valerii E. Orel; Andrii  Shypko; Valerii  B. Orel; Donika  Ivanova; Christian  Pilarsky; Jing  Tang; Zhe-Sheng  Chen; Jian-ye  Zhang

doi:10.17305/bjbms.2021.6484

Authors

Xin-yue Fan Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Zhuo-fen Deng Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Yan-yan Yan Institute of Immunology, School of Medicine, Shanxi Datong University, Datong, China
Valerii E. Orel Medical Physics and Bioengineering Research Laboratory, National Cancer Institute, Kyiv, Ukraine ; Faculty of Biomedical Engineering, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine
Andrii Shypko Medical Physics and Bioengineering Research Laboratory, National Cancer Institute, Kyiv, Ukraine
Valerii B. Orel Medical Physics and Bioengineering Research Laboratory, National Cancer Institute, Kyiv, Ukraine. ; Faculty of Biomedical Engineering, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine
Donika Ivanova Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Christian Pilarsky Department of Surgery, Friedrich-Alexander University of Erlangen- Nuremberg (FAU) and University Hospital of Erlangen, Erlangen, Germany
Jing Tang Institute for Molecular Medicine Finland (FIMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland https://orcid.org/0000-0001-7480-7710
Zhe-Sheng Chen Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY, United States https://orcid.org/0000-0002-8289-097X
Jian-ye Zhang Key Laboratory of Molecular Target and Clinical Pharmacology and the State and NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China https://orcid.org/0000-0001-5242-3687

DOI:

https://doi.org/10.17305/bjbms.2021.6484

Keywords:

Microfluidic chip, anticancer drug screening, high throughput screening

Abstract

With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.