Breast MRI, digital mammography and breast tomosynthesis: comparison of three methods for early detection of breast cancer

  • Dragana Roganovic Dom zdravlja Banjaluka
  • Dragana Djilas Diagnostic Imaging Center, Oncology Institute of Vojvodina, Novi Sad
  • Sasa Vujnovic Institute of Clinical Radiology, University Hospital Clinical Center Banjaluka
  • Dag Pavic Department of Radiology, Medical University of South Carolina, Charleston, SC
  • Dragan Stojanov Faculty of Medicine University of Nis, Department of Radiology, Nis
Keywords: breast, breast MRI, breast tomosynthesis, digital mammography

Abstract

Breast cancer is the most common malignancy in women and early detection is important for its successful treatment. The aim of this study was to investigate the sensitivity and specificity of three methods for early detection of breast cancer: breast magnetic resonance imaging (MRI), digital mammography, and breast tomosynthesis in comparison to histopathology, as well as to investigate the intraindividual variability between these modalities.  We included 57 breast lesions, each detected by three diagnostic modalities: digital mammography, breast MRI, and breast tomosynthesis, and subsequently confirmed by histopathology. Breast Imaging-Reporting and Data System (BI-RADS) was used for characterizing the lesions. One experienced radiologist interpreted all three diagnostic modalities. Twenty-nine of the breast lesions were malignant while 28 were benign. The sensitivity for digital mammography, breast MRI, and breast tomosynthesis, was 72.4%, 93.1%, and 100%, respectively; while the specificity was 46.4%, 60.7%, and 75%, respectively. Receiver operating characteristics (ROC) curve analysis showed an overall diagnostic advantage of breast tomosynthesis over both breast MRI and digital mammography. The difference in performance between breast tomosynthesis and digital mammography was significant (p < 0.001), while the difference between breast tomosynthesis and breast MRI was not significant (p = 0.20). 

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Author Biographies

Dragana Roganovic, Dom zdravlja Banjaluka

Department of radiology,

MD, MSC, radiologist

Dragana Djilas, Diagnostic Imaging Center, Oncology Institute of Vojvodina, Novi Sad
MD, PhD
Sasa Vujnovic, Institute of Clinical Radiology, University Hospital Clinical Center Banjaluka
MD, PhD
Dag Pavic, Department of Radiology, Medical University of South Carolina, Charleston, SC

MD, Associate Professor of Radiology

Dragan Stojanov, Faculty of Medicine University of Nis, Department of Radiology, Nis

MD, Prof.

 

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Published
2015-11-16
How to Cite
1.
Roganovic D, Djilas D, Vujnovic S, Pavic D, Stojanov D. Breast MRI, digital mammography and breast tomosynthesis: comparison of three methods for early detection of breast cancer. Bosn J of Basic Med Sci [Internet]. 2015Nov.16 [cited 2019Nov.19];15(4):64-8. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/616
Section
Translational and Clinical Research