The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

  • Selami Demirelli Erzurum Education and Research Hospital
  • Husnu Degirmenci Erzincan Universty
  • Emrah Ermis Erzurum Education and Research Hospital
  • Sinan Inci Aksaray State Hospital
  • Gokay Nar Aksaray State Hospital
  • Mehmet Emin Ayhan Erzurum Education and Research Hospital
  • Serdar Fırtına Maresal Cakmak Military Hospital
  • Hikmet Hamur Erzincan Universty
  • Senay Arikan Durmaz Erzurum Education and Research Hospital
Keywords: Polycystic ovary syndrome, speckle tracking echocardiography, subclinical left ventricular dysfunction

Abstract

Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants’ ages ranged between 18 and 40 years. PCOS was diagnosed according to the Rotterdam criteria. LV strain (LS) and strain rate (SR) were evaluated using apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) imaging. Global LS and SR were calculated as average of three apical views. The waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and fasting insulin and triglyceride levels were higher in the PCOS group than in the controls (p = 0.001, p = 0.001, p = 0.001, and p = 0.005, respectively). In the PCOS group, the mitral A wave, deceleration time (DT), and isovolumetric relaxation time (IVRT) were significantly higher than in the controls (all p< 0.05). The LV global longitudinal strain (GLS) and global longitudinal SR systolic (GLSRS) were significantly lower in the PCOS patient group (both p = 0.001). There were strong negative correlations between GLS and both fasting insulin (r = −0.64) and DT (r = –0.62) (both p < 0.05). The study demonstrated that PCOS patients had decreased LV function using STE. Therefore, STE imaging appears to be useful for the early detection of subclinical LV dysfunction in patients with PCOS.

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Author Biographies

Selami Demirelli, Erzurum Education and Research Hospital
Cardiology
Husnu Degirmenci, Erzincan Universty
Cardiology
Emrah Ermis, Erzurum Education and Research Hospital
Cardiology
Sinan Inci, Aksaray State Hospital
Cardiology
Gokay Nar, Aksaray State Hospital
Cardiology
Mehmet Emin Ayhan, Erzurum Education and Research Hospital
Internal Medicine
Serdar Fırtına, Maresal Cakmak Military Hospital
Cardiology
Hikmet Hamur, Erzincan Universty
Cardiology
Senay Arikan Durmaz, Erzurum Education and Research Hospital
Internal Medicine

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Published
2015-10-19
How to Cite
1.
Demirelli S, Degirmenci H, Ermis E, Inci S, Nar G, Ayhan ME, Fırtına S, Hamur H, Durmaz SA. The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome. Bosn J of Basic Med Sci [Internet]. 2015Oct.19 [cited 2019Nov.20];15(4):44-9. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/552
Section
Translational and Clinical Research