Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism

  • Nuri Köse Department of Cardiology, Private Mugla Yucelen Hospital, Mugla, Turkey https://orcid.org/0000-0001-8658-2598
  • Tarık Yıldırım Department of Cardiology, Faculty of Medicine, Balikesir University, Balıkesir, Turkey https://orcid.org/0000-0002-6314-7371
  • Fatih Akın Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  • Seda Elçim Yıldırım Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
  • İbrahim Altun Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
Keywords: Pulmonary embolism, neutrophil to lymphocyte ratio, NLR, platelet to lymphocyte ratio, PLR, lymphocyte to monocyte ratio, LMR, prognosis, patient outcomes

Abstract

Pulmonary embolism (PE) is associated with significant morbidity and mortality. New biological markers are being investigated for estimating the prognosis of PE patients. Since PE is closely associated with inflammatory status, the neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), and lymphocyte-monocyte (LMR) ratios were suggested to be useful in predicting patient outcomes. This study aimed to evaluate the prognostic role of NLR, PLR, and LMR in PE. A total of 103 PE cases from a cardiology department were included in the study. Control group consisted of 102 patients selected from outpatient clinics other than cardiology, cardiovascular surgery, and chest diseases. We retrospectively evaluated demographic and clinical characteristics, treatments, laboratory and imaging findings, and outcomes of patients. The median follow-up of PE patients was 39 months, and the 5-year overall survival probability was 73.8%. Out of 103 patients, 20 were classified as high risk PE cases (19.4%). Thrombolytic treatment was administered to 23 patients (22.3%). Systolic pulmonary arterial pressure was measured during one year, showing a significant decrease from 51.7 ± 15.7 mmHg at admission to 26.6 ± 4.0 mmHg at first year assessment. Age (OR: 1.06, p < 0.001) and NLR (OR: 1.52, p < 0.0019) were significantly associated with the disease status. The independent prognostic factors in moderate-low and low risk PE groups were NLR (HR: 1.17, p = 0.033) and LMR (HR: 1.58, p = 0.046). In moderate-high and high risk PE patients, the independent prognostic factors were age (HR: 1.07, p = 0.014) and PLR (HR: 1.01, p = 0.046). NLR, PLR, and LMR were associated with the prognosis of PE patients. The clinical severity of PE should be considered when utilizing these markers to assess patient outcomes.

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Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism
Published
2019-11-13
How to Cite
1.
Köse N, Yıldırım T, Akın F, Yıldırım SE, Altun İbrahim. Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism. Bosn J of Basic Med Sci [Internet]. 2019Nov.13 [cited 2019Dec.11];00. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/4445
Section
Translational and Clinical Research