Fractalkine receptor polymorphism may not be associated with the development and clinical course of ulcerative colitis

  • Hale Gokcan Ankara Yüksek İhtisas Research and Training Hospital, Department of gastroenterology
  • Erkan Yurtcu Baskent University, Medical Faculty, Deptarment of Medical Biology
  • Haldun Selcuk Baskent University, Medical Faculty, Department of Gastroenterology
  • Feride Iffet Sahin Baskent University, Medical Faculty, Department of Medical Genetics
Keywords: Fractalkine, CX3CR1 polymorphism, ulcerative colitis

Abstract

Fractalkine (CX3C), a chemokine expressed by epithelial cells within normal and inflamed colorectal mucosa, induces leukocyte adhesion and migration via fractalkine receptor. The aim of this study was to investigate two single nucleotide polymorphisms of the fractalkine receptor gene as a risk factor both for the development and clinical findings of ulcerative colitis. In this study, 51 patients with ulcerative colitis (UC) and 80 controls were recruited. Genotypes of fractalkine receptor c.745G>A (V249I) and c.839C>T (T280M) polymorphisms were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.Genotype distribution and allele frequencies of V249I and T280M were not statistically significantly different between UC and control groups (p>0.05). No statistically significant relationship was found between fractalkine receptor polymorphisms and clinical findings of UC. We observed no significant difference in fractalkine receptor polymorphism between patients and control group and no genotype-phenotype relation. Therefore, we concluded that fractalkine receptor polymorphisms may not contribute to the molecular pathogenesis of UC.

 

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Published
2015-05-25
How to Cite
1.
Gokcan H, Yurtcu E, Selcuk H, Sahin FI. Fractalkine receptor polymorphism may not be associated with the development and clinical course of ulcerative colitis. Bosn J of Basic Med Sci [Internet]. 2015May25 [cited 2019Nov.14];15(2):73-7. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/387
Section
Translational and Clinical Research