The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients

  • Senija Rašić Institute of Nephrology
  • Indira Kulenović Department of Endocrinology and Diabetes
  • Irfan Zulić Institute for Pharmacology and Toxicology - Medical Faculty University of Sarajevo
  • Azra Haračić Department of Cardiology - Clinical Centre University of Sarajevo
  • Mithat Čengić Institute of Nephrology
  • Snježana Unčanin Institute of Nephrology
  • Jasminka Džemidžić Institute of Nephrology
Keywords: erythropoietin treatment, left ventricular hyperthrophy, haemodialysis patients

Abstract

Anaemia appears to play an important role in left ventricular (LV) enlargement in chronic kidney disease patients. The objective of this study was to evaluate LV echocardiography changes during anaemia correction with recombinant human erythropoietin(rHu-Epo) in chronic haemodialysis patients (HD pts) with signs of anaemia and LV hypertrophy (LVH). The study included 20 HD pts aged 39,6 +/- 5,3 yrs, with the same condition of HD treatment, anaemia and echocardiographically LVH verified. At the beginning of the rHu-Epo treatment haemoglobin (Hb) level was < 90 g/L and the target Hb level was 110 g/L. Echocardiography was performed at the beginning (baseline) and after six months of rHu-Epo treatment. LVH was defined as LV mass index >100 g/m2 in women and >131 g/m2 in men. We observed significant reduction of LV mass index (LVMI) (mean 26,4%, p=0.008), as well as LV volumen. There was a significant negative correlation between Hb level and LVMI with predictive LVMI reduction of 2,317 g/m2 for each 1g/L rising of mean Hb level. The results of the study confirm the importance of early anaemia correction in haemodialysis patients aimed to improve LV parameters.

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The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients
Published
2003-11-20
How to Cite
1.
Rašić S, Kulenović I, Zulić I, Haračić A, Čengić M, Unčanin S, Džemidžić J. The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients. Bosn J of Basic Med Sci [Internet]. 2003Nov.20 [cited 2021Apr.15];3(4):11-5. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/3485
Section
Translational and Clinical Research