Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins

Radivoj Jadrić; Sabaheta Hasić; Emina Kiseljaković; Jovan Radovanović; Emina Ićindić-Nakaš; Mira Winterhalter-Jadrić

doi:10.17305/bjbms.2006.3124

Authors

Radivoj Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Sabaheta Hasić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Emina Kiseljaković Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Jovan Radovanović Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Emina Ićindić-Nakaš Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
Mira Winterhalter-Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2006.3124

Keywords:

amitryptilin, beta-endorphins, rat, sera, brain

Abstract

The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.