Effect of War and Postwar Genotoxins on Micronuclei Frequency in Sarajevo Study Group

Slavka Ibrulj; Sanin Haverić; Anja Haverić; Adaleta Durmić-Pašić; Damir Marjanović

doi:10.17305/bjbms.2006.3121

Authors

Slavka Ibrulj Institute for Genetic Engineering and Biotechnology, University of Sarajevo, Faculty of Medicine, University of Sarajevo
Sanin Haverić Institute for Genetic Engineering and Biotechnology, University of Sarajevo
Anja Haverić Institute for Genetic Engineering and Biotechnology, University of Sarajevo
Adaleta Durmić-Pašić Institute for Genetic Engineering and Biotechnology, University of Sarajevo
Damir Marjanović Institute for Genetic Engineering and Biotechnology, University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2006.3121

Keywords:

war related genotoxins, binuclear lymphocytes, micronuclei

Abstract

During the 1992-1995 siege, as well as after the war activities, citizens of Sarajevo were most probably exposed to various potential genotoxic agents. The effects of those potential genotoxins were evaluated by micronucleus-cytokinesis blocked assay. The study included 30 individuals who resided in the area of Sarajevo during the war and the postwar period. Point bi-serial coefficient analysis did not reveal any relationship between the frequencies of binuclear cells with micronuclei as well as total number of micronuclei and smoking habits or gender. Simple linear regression revealed statistically significant positive correlation between the age and micronuclei formation. Due to the war related environmental contamination more extensive study is recommended.