ß-endorphins as Possible Markers for Therapeutic Drug Monitoring

Authors

  • Radivoj Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Emina Kiseljaković Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Sabaheta Hasić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo
  • Mira Winterhalter-Jadrić Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2007.3081

Keywords:

amitriptyline, trazodone, β-endorphins, rat, brain

Abstract

This study was performed in order to investigate possible role of brain beta-endorphins as markers of antidepressive drugs therapy monitoring. Experiment was done using amitriptyline and trazodone as antidepressants. For quantification of brain beta-endorphins we used RIA technique. Our results showed significant decrease of brain beta-endorphins concentration in drug-pretreated animals, vs. those in of control group treated with 0,95% NaCl. The lower values were obtained in trazodone pre-treated animals. This study shows that use of psychoactive drugs have influence on brain beta-endorphins concentration. beta-endorphins could be of great importance, used as markers for evaluation of patient treatment.

ß-endorphins as Possible Markers for Therapeutic Drug Monitoring

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Published

20-02-2007

How to Cite

1.
ß-endorphins as Possible Markers for Therapeutic Drug Monitoring. Biomol Biomed [Internet]. 2007 Feb. 20 [cited 2024 Mar. 28];7(1):11-5. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/3081