Effects of Fixed Combination of Lisinopril Plus Hydrochlorothiazide on Regression of Left Ventricular Hypertrophy in Patients With Essential Hypertension: An Opened, Multi-Centre, Prospective Clinical Trial

Vjekoslav Gerc; Begler Begović; Midhat Vehabović; Leonid Georgievich Voronkov; Eleonora Vataman; Ljiljana Musić; Marko Bukša; Zumreta Kušljugić; Fahir Baraković; Vera Iosifovna Tchelujko; Alexander Ivanovich Dyaduk; Svetlana Alekseevna Andrievskaja; Andrey Eduardovich Bagrij; Sergey Nikolaevich Polivoda; Aleksandar Lazarević; Božidarka Knežević; Faik Hima

doi:10.17305/bjbms.2008.2920

Authors

Vjekoslav Gerc Clinic for Heart Diseases and Rheumatism, University of Sarajevo Clinics Centre
Begler Begović Institute for Clinical Pharmacology, Clinics Center University of Sarajevo
Midhat Vehabović Bosnalijek dd
Leonid Georgievich Voronkov Institute of Cardiology of Academy of Medical Sciences of Ukraine
Eleonora Vataman Scientific Departments of Medicale
Ljiljana Musić Clinic for Heart Diseases, Clinical Center of Montenegro
Marko Bukša Clinic for Heart Diseases and Rheumatism, University of Sarajevo Clinics Centre
Zumreta Kušljugić Department of Cardiology, University Clinical Center Tuzla
Fahir Baraković Department of Cardiology, University Clinical Center Tuzla
Vera Iosifovna Tchelujko City Hospital No 8
Alexander Ivanovich Dyaduk City Hospital No 1
Svetlana Alekseevna Andrievskaja Regional Cardiological Clinic
Andrey Eduardovich Bagrij City Hospital No 1
Sergey Nikolaevich Polivoda Regional Clinical Hospital
Aleksandar Lazarević Clinic for Internal Diseases, Clinical Centre
Božidarka Knežević Clinic for Heart Diseases, Clinical Center of Montenegro
Faik Hima Internal Clinic UCC Pristina

DOI:

https://doi.org/10.17305/bjbms.2008.2920

Keywords:

lisinopril, hydrochlorothiazide, left ventricular hypertrophy, hypertension, clinical trial

Abstract

The aim of this trial was to examine the effects of antihypertensive fixed combination of lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd, Bosnia and Herzegovina) on regression of left ventricular hypertrophy in patients with essential arterial hypertension. We included 297 patients in our trial, aged 54,65±9,6 years, with treated or untreated hypertension and with high risk of cardiac events, in an opened trial of therapy based on lisinopril plus hydrochlorothiazide. Patients from five European countries were followed up for a period of 12 weeks. Duration of treatment was 12 weeks. We adjusted daily doses of lisinopril plus hydrochlorothiazide after every clinical examination and recorded adverse effects of drugs.

In the beginning and after 12 weeks of treatment, 277 patients (93,2%) underwent 2-dimensional echocardiography and there were 186 patients evaluated for efficacy of treatment on left ventricular hypertrophy (LVH). We recorded a regression of index mass LVH (168,56 vs 161,51 g/m², P<0,0001), and regression was something more in women vs men.

We recorded average reduction of left ventricular mass index for patients with LVH (N=186) by 7,05 g/m² (4,18%) in all patients, by 6,73 g/m² (3,93%) in men and 7,27 g/m² (4,37%) in women. The proportion of patients who attained a regression of left ventricular mass tended to be greater in men (54,55% vs 53,21%).

This research has proved regression of LVH in more than 53% patients after using fixed combination of lisinopril plus hydrochlorothiazide.