Imaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL)


  • Dragan Stojanov Faculty of Medicine University of Niš, Serbia Center of Radiology, Clinical Center Niš, Serbia
  • Slobodan Vojinovic
  • Aleksandra Aracki-Trenkic
  • Aleksandar Tasic
  • Daniela Benedeto-Stojanov
  • Srdjan Ljubisavljevic
  • Sasa Vujnovic



CADASIL, MRI, computed tomography, white matter hyperintensities, cerebral microbleeds


Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is an autosomal dominant vascular disorder. Diagnosis and follow-up in patients with CADASIL are based mainly on magnetic resonance imaging (MRI). MRI shows white matter hyperintensities (WMHs), lacunar infarcts and cerebral microbleeds (CMBs). WMHs lesions tend to be symmetrical and bilateral, distributed in the periventricular and deep white matter. The anterior temporal lobe and external capsules are predilection sites for WMHs, with higher specificity and sensitivity of anterior temporal lobe involvement compared to an external capsule involvement. Lacunar infarcts are presented by an imaging signal that has intensity of cerebrospinal fluid in all MRI sequences. They are localized within the semioval center, thalamus, basal ganglia and pons. CMBs are depicted as focal areas of signal loss on T2 images which increases in size on the T2*-weighted gradient echo planar images (“blooming effect”).



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Imaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL)


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Imaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL). Biomol Biomed [Internet]. 2015 Feb. 9 [cited 2024 Jul. 19];15(1):1-8. Available from: