Plasma leptin values in postmenopausal women with osteoporosis

  • Hikmet Kocyigit Department of Physical Medicine and Rehabilitation, Izmir Katip Celebi University, Atatürk Training and Research Hospital
  • Serpil Bal Department of Physical Medicine and Rehabilitation, Izmir Katip Celebi University, Atatürk Training and Research Hospital
  • Ayşenur Atay Department of Biochemistry, Izmir Katip Celebi University, Atatürk Training and Research Hospital
  • Mehmet Koseoglu Department of Biochemistry, Izmir Katip Celebi University, Atatürk Training and Research Hospital
  • Alev Gurgan Department of Physical Medicine and Rehabilitation, Izmir Katip Celebi University, Atatürk Training and Research Hospital
Keywords: Bone density, leptin, obesity, postmenopausal osteoporosis

Abstract

Obesity has a protective effect against osteoporosis and this effect has been attributed to a high body fat content. It has been shown that the leptin concentration is higher in obese patients. Leptin, the protein product of obesity gene, is a hormone produced in adipose tissue. Some studies suggest that endogenous leptin might influence bone metabolism in postmenopausal women. In this study, we investigated plasma leptin concentrations in postmenopausal women with osteoporosis and also analyzed the relationship between plasma leptin levels and bone mineral density (BMD) in order to understand the potential role of leptin in maintaining bone mass. Forty-two postmenopausal women with osteoporosis and thirty seven age and BMI-matched healthy postmenopausal women were included in the study. The mean femoral neck BMD value in the patient group was significantly lower than that in the control group (0.691±0.1 g/cm1 and 0.863±0.1 g/cm2, respectively; p<0.001). The mean plasma leptin concentration in the patient group was not significantly different from that in the control group (p>0.05). Plasma leptin levels were correlated with BMI in both groups (p<0.001 in the patient group and p=0.001 in controls). There was also a strong positive correlation between plasma leptin levels and %fat in both groups (p<0.001 in the patient group and p<0.001 in controls). But there was no correlation between plasma leptin levels and femoral neck BMD values in both groups. Our results do not support the hypothesis that leptin itself plays an important role in maintaining bone mass in postmenopausal women.

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Plasma leptin values in postmenopausal women with osteoporosis
Published
2013-08-20
How to Cite
1.
Kocyigit H, Bal S, Atay A, Koseoglu M, Gurgan A. Plasma leptin values in postmenopausal women with osteoporosis. Bosn J of Basic Med Sci [Internet]. 2013Aug.20 [cited 2020Aug.3];13(3):192-6. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/2361
Section
Biochemistry