Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction

  • Nermana Mehić-Basara Public Institute for Alcoholism and Substance Abuse Sarajevo
  • Lilijana Oruč Psychiatric Clinic, Clinical Center University of Sarajevo
  • Lejla Kapur-Pojskić Institute for Genetic Engineering and Biotechnology
  • Jasmin Ramić Institute for Genetic Engineering and Biotechnology
Keywords: opioid addiction, heroin, genetics, MMT, DRD2, EPQ, personality traits, PAS-psychoactive substance, genetic association

Abstract

There is a clear evidence that same psychoactive substance may cause various individual physiological reactions in same environmental conditions. Although there is a general attitude on equal liability to opioid addiction, latest genetic analysis findings imply there are certain quantifiable factors that could lead to elevated individual liability towards development of opioid addiction. The goal of this study was to investigate association of certain personality traits and genetic factors (separately and in combination) with heroin addiction. Total of 200 individuals participated in the study: 100 patients on Metadone Maintenance Treatment (MMT) and 100 age and sex matched healthy volunteers. All were medically examined, interviewed and psychologically evaluated using Eysenck personality questionnaire (EPQ) and genotyped for DRD2 (rs1800497) using PCR-RFLP method. Overrepresentation of certain personality traits (neuroticism, psychoticism and extraversion/intraversion), together with environemental risk factors such as: upbringing within incomplete families and familial history of psychotropic substances abuse, are associated with high-risk development of opioid addiction.

Downloads

Download data is not yet available.
Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction
Published
2013-08-20
How to Cite
1.
Mehić-BasaraN, Oruč L, Kapur-PojskićL, Ramić J. Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction. Bosn J of Basic Med Sci [Internet]. 2013Aug.20 [cited 2020Nov.27];13(3):158-62. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/2355
Section
Translational and Clinical Research