Stereological analysis of terminal villi of the placentas of pregnant woman with sideropenic anemia

  • Melisa Lelic University of Tuzla Medical Faculty Univerzitetska 1, Tuzla Bosnia and Herzegovina
  • Suada Ramic
  • Zlata Zigic
  • Gordana Bogdanovic
  • Sergije Markovic
Keywords: placenta, terminal villi, pregnancy anemia, stereology


Iron deficiency, causing maternal sideropenic anemia, is one of the most frequent nutritive disorder that develops during the pregnancy. We collected 30 placentas from anemic mothers and 30 placentas from mothers belonging to the control group. Terminal villi (magnification 10x) and terminal villi capillaries (magnification 40x) were stereologically analyzed and numerically determined.

In the placentas from anemic mothers we noted the values a) terminal villi: volume density 0,43 mm0, surface density 24.13 mm-1, total volume 185.57 cm3 and total surface 10.27 m2; b) capillaries of terminal villi: volume density 0.53 mm0 and total volume 224.18 cm3. In the placentas from mothers belonging to the control group we observed the following values a) terminal villi: volume density 0.44 mm0, surface density 22.27 mm-1, total volume 200.17 cm3 and total surface 10.15 m2; b) capillaries of terminal villi: volume density 0.42 mm0 and total volume 197.00 cm3. Compared with the control group anemic mothers' placentas have a significant higher values of surface density of terminal villi (p<0.05), volume density (p <0.01) and absolute volume (p<0.0001) of terminal villi capillaries, and significant lower values of absolute volume of terminal villi (p<0.05).

In anemic mothers’ placentas, the total volume of terminal villi changes disproportionately to the total surface of terminal villi with statistically significant increase of terminal villi capillaries compared with control group. 


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Author Biography

Melisa Lelic, University of Tuzla Medical Faculty Univerzitetska 1, Tuzla Bosnia and Herzegovina

Department for histology and embriology

MD, asisstant


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Stereological analysis of terminal villi of the placentas of pregnant woman with sideropenic anemia
How to Cite
Lelic M, Ramic S, Zigic Z, Bogdanovic G, Markovic S. Stereological analysis of terminal villi of the placentas of pregnant woman with sideropenic anemia. Bosn J of Basic Med Sci [Internet]. 2014Aug.18 [cited 2021Jan.22];14(3):139-43. Available from: