Mammary Analogue Secretory Carcinoma (MASC) of the salivary gland: A  new tumor entity

Ivan Damjanov; Faruk Skenderi; Semir Vranic

doi:10.17305/bjbms.2016.1321

Authors

Ivan Damjanov Department of Pathology and Laboratory Medicine, The University of Kansas School of Medicine, Kansas City, KS, United States of America
Faruk Skenderi Department of Pathology, Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Semir Vranic Department of Pathology, Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

DOI:

https://doi.org/10.17305/bjbms.2016.1321

Keywords:

salivary gland, carcinoma, mammary analogue, MASC

Abstract

Mammary analogue secretory carcinoma (MASC) is a recently described low-grade malignant tumor of the salivary glands, biologically and morphologically equivalent to secretory breast carcinoma. We give a brief overview of this new entity, including morphological, immunohistochemical, molecular-genetic, clinical, epidemiologic features, differential diagnosis, and outcome results.

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References

Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, et al.

Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599-608.

DOI: 10.1097/PAS.0b013e3181d9efcc.

Wenig BM. Atlas of head and neck pathology. 3rd ed. Philadelphia: Elsevier; 2016.

Oza N, Sanghvi K, Shet T, Patil A, Menon S, Ramadwar M, et al. Mammary analogue secretory carcinoma of parotid: is preoperative cytological diagnosis possible? Diagn Cytopathol. 2016 Mar 4. [Epub ahead of print]

http://dx.doi.org/10.1002/dc.23459.

Jung MJ, Kim SY, Nam SY, Roh JL, Choi SH, Lee JH, et al. Aspiration cytology of mammary analogue secretory carcinoma of the salivary gland. Diagn Cytopathol. 2015;43:287-93.

http://dx.doi.org/10.1002/dc.23208.

Urano M, Nagao T, Miyabe S, Ishibashi K, Higuchi K, Kuroda M. Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers. Hum Pathol. 2015;46:94-103.

http://dx.doi.org/10.1016/j.humpath.2014.09.012.

Ito Y, Ishibashi K, Masaki A, Fujii K, Fujiyoshi Y, Hattori H, et al. Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion. Am J Surg Pathol. 2015;39:602-10.

http://dx.doi.org/10.1097/PAS.0000000000000392.

Skálová A, Vanecek T, Simpson RH, Laco J, Majewska H, Baneckova M, et al. Mammary analogue secretory carcinoma of salivary glands: molecular analysis of 25 ETV6 gene rearranged tumors with lack of detection of classical ETV6-NTRK3 fusion transcript by standard RT-PCR: report of 4 cases harboring ETV6-X gene fusion. Am J Surg Pathol. 2016;40:3-13.

http://dx.doi.org/10.1097/PAS.0000000000000537.

Skálová A, Vanecek T, Majewska H, Laco J, Grossmann P, Simpson RH, et al. Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes. Am J Surg Pathol. 2014;38:23-33.

http://dx.doi.org/10.1097/PAS.0000000000000088.

Drilon A, Li G, Dogan S, Gounder M, Shen R, Arcila M, et al. What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC). Ann Oncol. 2016 Feb 15. pii: mdw042. [Epub ahead of print]

http://dx.doi.org/10.1093/annonc/mdw042.

Luk PP, Selinger CI, Eviston TJ, Lum T, Yu B, O'Toole SA, et al. Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics. Pathology. 2015; 47:659-66. http://dx.doi.org/10.1097/PAT.0000000000000322.

Majewska H, Skálová A, Stodulski D, Klimková A, Steiner P, Stankiewicz C, et al. Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement. Virchows Arch. 2015;466:245-54. http://dx.doi.org/10.1007/s00428-014-1701-8.