Role of Fascin-1 in cervical cancer metastasis via Wnt/β-catenin pathway activation

Authors

  • Yan Wang Department of Gynecology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei province, China
  • Wei Cui Department of Gynecology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei province, China
  • Dong-Mei Chu Department of Gynecology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei province, China

DOI:

https://doi.org/10.17305/bb.2025.12114

Keywords:

Fascin-1, cervical cancer, CC, activating Wnt/β-catenin pathway

Abstract

This investigation delves into the impact of Fascin-1, a protein known for its role in actin bundling and its association with metastatic enhancement, on the advancement of cervical cancer. Elevated levels of Fascin-1 have been observed in metastatic carcinomas, but its impact on gene regulation in cervical cancer has not been thoroughly studied. Our research demonstrates a marked elevation in the expression of Fascin-1 within tissues affected by cervical cancer. Experiments employing both overexpression and knockdown methods revealed that Fascin-1 plays a critical role in promoting the proliferation and mobility of cervical cancer cells in vitro. Correspondingly, reducing Fascin-1 levels led to a marked decrease in tumor growth and metastatic spread in vivo. At the molecular level, diminishing Fascin-1 expression resulted in decreased β-catenin and C-myc RNA and protein levels. This implies that Fascin-1 could intensify the progression of cervical cancer by influencing the Wnt/β-catenin signaling cascade. This study not only elucidates the mechanism by which Fascin-1 contributes to the advancement of cervical cancer but also proposes a novel approach for therapeutic intervention.

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Role of Fascin-1 in cervical cancer metastasis via Wnt/β-catenin pathway activation

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Published

14-03-2025

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Research article

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How to Cite

1.
Role of Fascin-1 in cervical cancer metastasis via Wnt/β-catenin pathway activation. Biomol Biomed [Internet]. 2025 Mar. 14 [cited 2025 Mar. 31];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/12114