Function and mechanism of miRNAs during the process of Klebsiella pneumoniae infection

Chuhan Zhang; Ge Li; Safi  Ullah; Liang Liu; Huajie Zhao; Fan Yang; Liwei  Guo; Duan Li

doi:10.17305/bb.2025.11421

Authors

Chuhan Zhang Department of Pathogenic Biology, School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China; School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China https://orcid.org/0009-0008-7665-9107
Ge Li Department of Pathogenic Biology, School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China; School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China https://orcid.org/0009-0009-9598-2759
Safi Ullah School of International Education, Xinxiang Medical University, 453003, Xinxiang, Henan, China https://orcid.org/0009-0007-9222-4958
Liang Liu Department of Pathogenic Biology, School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China
Huajie Zhao Department of Pathogenic Biology, School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China
Fan Yang Department of Pathogenic Biology, School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China
Liwei Guo School of Forensic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China
Duan Li Department of Pathogenic Biology, School of Basic Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, China

DOI:

https://doi.org/10.17305/bb.2025.11421

Keywords:

Klebsiella pneumoniae, miRNAs, lung infection, peritonitis, sepsis

Abstract

Klebsiella pneumoniae (K. pneumoniae), a Gram-negative bacterium, is a major cause of nosocomial infections and can lead to severe, widespread infections. The rise of hypervirulent and multidrug-resistant K. pneumoniae presents significant challenges to public health. Diseases associated with K. pneumoniae, such as pneumonia, lung injury, peritonitis, and sepsis, have garnered increasing attention. MicroRNAs (miRNAs) are a class of short, endogenously expressed non-coding RNAs that regulate gene expression by inhibiting translation or promoting mRNA degradation. As key regulators of gene expression, miRNAs play a crucial role in K. pneumoniae infections by modulating host inflammatory pathways, suppressing inflammasome activity, regulating cytokine secretion, and facilitating post-translational modifications. Understanding miRNA alterations and their mechanisms during K. pneumoniae infections is of great significance. This comprehensive review explores the functions and mechanisms of miRNAs in K. pneumoniae-induced lung injury, peritonitis, and sepsis. By analyzing differential miRNA expression during infection, we aim to provide new insights and potential directions for future clinical diagnosis and treatment strategies for K. pneumoniae infections.