Research progress on miRNAs function in the interaction between human infectious viruses and hosts: A review

Authors

  • Xiaotong Wang Heilongjiang University of Traditional Chinese Medicine, Heilongjiang, China
  • Wenchang Zhao School of Pharmacy, Guangdong Medical University, Dongguan, China

DOI:

https://doi.org/10.17305/bb.2024.10821

Keywords:

MicroRNAs, virus, virus-host interactions

Abstract

MicroRNAs (miRNAs) represent a class of non-coding small RNAs that are prevalent in eukaryotes, typically comprising approximately 22 nucleotides, and have the ability to post-transcriptionally regulate gene expression. miRNAs exhibit diverse types and functions, with mechanisms of action that include cell differentiation, proliferation, apoptosis, and regulation of signaling pathways. Both viruses and their hosts can encode miRNAs, which serve as crucial effector molecules in the complex interaction between viruses and host cells. Host miRNAs can either directly interact with the virus genome to inhibit virus replication or facilitate virus replication by providing necessary substances. Viral miRNAs can directly bind to host mRNAs, thereby influencing translation efficiency, suppressing the immune response, and ultimately enhancing virus replication. This article comprehensively reviews the roles of miRNAs in virus-host interactions, aiming to provide valuable insights into viral pathogenic mechanisms and potential therapeutic approaches.

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Research progress on miRNAs function in the interaction between human infectious viruses and hosts: A review

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Published

17-10-2024

Issue

Section

Review

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How to Cite

1.
Research progress on miRNAs function in the interaction between human infectious viruses and hosts: A review. Biomol Biomed [Internet]. 2024 Oct. 17 [cited 2024 Dec. 11];24(6):1452–1462. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/10821