The efficacy of Salvia-ligustrazine and Ligustrazine in treating gestational hypertension: A systematic review and meta-analysis

Authors

  • Ruyi Ji School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China https://orcid.org/0009-0005-3495-3744
  • Qianrong Gan School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • Xinyao Shu School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • Ruitong Xu School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • Xinyu Huang School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • Tao Shen School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China

DOI:

https://doi.org/10.17305/bb.2024.10743

Keywords:

Pregnancy-induced hypertension syndrome (PIH), Salvia-ligustrazine, Ligustrazine, meta-analysis

Abstract

Pregnancy-induced hypertension syndrome (PIH), a prevalent and critical condition, has garnered increasing attention due to its significant impact on maternal and fetal health outcomes. The conventional treatment approaches rely on magnesium sulfate and various antihypertensive drugs; however, the clinical efficacy of these treatments is limited, highlighting the need to explore alternative avenues for improvement. Recently, a growing number of clinical studies have investigated the use of Salvia-ligustrazine or Ligustrazine in combination with conventional therapy. A comprehensive synthesis and critical analysis of these studies is necessary to evaluate the efficacy and safety of Salvia-ligustrazine or Ligustrazine in treating PIH. We sought all articles published prior to December 2, 2023, from seven databases to identify randomized controlled trials (RCTs) that involved traditional Chinese medicine Salvia-ligustrazine or Ligustrazine in combination with Western medicines for the conventional treatment of PIH, according to predefined inclusion criteria. The studies were assessed using the Cochrane Risk of Bias tool (ROB2.0), and meta-analyses were conducted using Stata 15.0 statistical software. We analyzed 47 RCTs encompassing 4,517 patients. The results demonstrated that combining Salvia-ligustrazine or Ligustrazine with Western medications was more efficacious than using Western medications alone. This combination improved the overall response rate, reduced the incidence of adverse pregnancy outcomes for mothers and infants, and decreased the occurrence of side effects associated with PIH treatment. While we evaluated the efficacy of traditional Chinese medicine injections of Salvia-ligustrazine or Ligustrazine alongside conventional Western treatments, our conclusions must be considered provisional due to potential bias and the limited availability of RCTs.

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The efficacy of Salvia-ligustrazine and Ligustrazine in treating gestational hypertension: A systematic review and meta-analysis

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Published

17-10-2024

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Section

Systematic review/Meta analysis

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How to Cite

1.
The efficacy of Salvia-ligustrazine and Ligustrazine in treating gestational hypertension: A systematic review and meta-analysis. Biomol Biomed [Internet]. 2024 Oct. 17 [cited 2024 Dec. 11];24(6):1517–1534. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/10743