The severity of intrahepatic cholestasis of pregnancy and its association with pregnancy complications and neonatal asphyxia: A single-center case analysis and systematic review

Siming Xin; Mengjiao Liu; Hua Lai; Liju Nie; Ying Hong; Yin Xiong; Xianxian Liu; Ting Wu; Xiaoming Zeng; Fen Fu

doi:10.17305/bb.2024.10588

Authors

Siming Xin Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Mengjiao Liu School of Public Health, Nanchang University, Nanchang, China
Hua Lai Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Liju Nie Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Ying Hong Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Yin Xiong Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Xianxian Liu Key Laboratory of Women’s Reproductive Health of Jiangxi Province, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Ting Wu School of Public Health, Nanchang University, Nanchang, China
Xiaoming Zeng Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Fen Fu Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China

DOI:

https://doi.org/10.17305/bb.2024.10588

Keywords:

Intrahepatic cholestasis of pregnancy, biochemical markers, adverse pregnancy outcomes, neonatal asphyxia, systematic review, meta-analysis

Abstract

Intrahepatic cholestasis of pregnancy (ICP) poses significant risks to maternal and neonatal health. Our study at Jiangxi Provincial Maternal and Child Health Hospital analyzed clinical and biochemical markers in singleton pregnancies diagnosed with ICP from October 2016 to December 2022. This research, supported by a systematic review and meta-analysis of existing studies, highlights the increasing incidence of ICP and its association with elevated levels of total bile acids, transaminases, and bilirubin. Our findings indicate a marked increase in the risk of preterm birth, cesarean delivery, and neonatal asphyxia as the severity of ICP escalates. This underscores the need for vigilant monitoring and management of affected pregnancies. By confirming the relationship between biochemical marker abnormalities and adverse pregnancy outcomes, our study advocates for enhanced clinical strategies and paves the way for future research aimed at improving prevention, diagnosis, and treatment methods for ICP.