Naringenin – a potential nephroprotective agent for diabetic kidney disease: A comprehensive review of scientific evidence

Authors

  • Estefania Valle-Velázquez Departamento de Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico https://orcid.org/0009-0006-6488-8450
  • Oscar René Zambrano-Vásquez Departamento de Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico https://orcid.org/0009-0005-6645-9054
  • Fernando Cortés-Camacho Departamento de Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico https://orcid.org/0009-0006-6697-546X
  • Laura Gabriela Sánchez-Lozada Departamento de Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • Gustavo Guevara-Balcázar Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico
  • Horacio Osorio-Alonso Departamento de Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico

DOI:

https://doi.org/10.17305/bb.2024.10511

Keywords:

Diabetes, chronic kidney disease (CKD), naringenin, oxidative stress, hypertension, inflammation

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by persistent hyperglycemia, which is a major contributing factor to chronic kidney disease (CKD), end-stage renal disease (ESRD), and cardiovascular-related deaths. There are several mechanisms leading to kidney injury, with hyperglycemia well known to stimulate oxidative stress, inflammation, tissue remodeling, and dysfunction in the vascular system and organs. Increased reactive oxygen species (ROS) decrease the bioavailability of vasodilators while increasing vasoconstrictors, resulting in an imbalance in vascular tone and the development of hypertension. Treatments for diabetes focus on controlling blood glucose levels, but due to the complexity of the disease, multiple drugs are often required to successfully delay the development of microvascular complications, including CKD. In this context, naringenin, a flavonoid found in citrus fruits, has demonstrated anti-inflammatory, anti-fibrotic, and antioxidant effects, suggesting its potential to protect the kidney from deleterious effects of diabetes. This review aims to summarize the scientific evidence of the effects of naringenin as a potential therapeutic option for diabetes-induced CKD.

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Naringenin – a potential nephroprotective agent for diabetic kidney disease: A comprehensive review of scientific evidence

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Published

17-10-2024

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Section

Review

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How to Cite

1.
Naringenin – a potential nephroprotective agent for diabetic kidney disease: A comprehensive review of scientific evidence. Biomol Biomed [Internet]. 2024 Oct. 17 [cited 2024 Dec. 12];24(6):1441–1451. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/10511