The relationship of peripheral blood lncRNA-PVT1 and miR-146a levels with Th17/Treg cytokines in patients with Hashimoto’s thyroiditis and their clinical significance

Authors

  • Yi-nan Li Department of Endocrinology 2, Central Hospital Affiliated to Shenyang Medical College, Tiexi District, Shenyang, Liaoning Province, China
  • Jingxue Shen Department of Endocrinology 2, Central Hospital Affiliated to Shenyang Medical College, Tiexi District, Shenyang, Liaoning Province, China
  • Yinglan Feng Department of Internal Medicine 1, Tacheng People's Hospital of Xinjiang, Tacheng, Xinjiang, China
  • Yingyan Zhang Department of Endocrinology 2, Central Hospital Affiliated to Shenyang Medical College, Tiexi District, Shenyang, Liaoning Province, China
  • Yusi Wang Department of Endocrinology 2, Central Hospital Affiliated to Shenyang Medical College, Tiexi District, Shenyang, Liaoning Province, China
  • Xinyu Ren Department of Endocrinology 2, Central Hospital Affiliated to Shenyang Medical College, Tiexi District, Shenyang, Liaoning Province, China

DOI:

https://doi.org/10.17305/bb.2024.10237

Keywords:

Long noncoding RNA, plasmacytoma variant translocation 1, miR-146a, Hashimoto’s thyroiditis, Th17, Treg, correlation

Abstract

Hashimoto’s thyroiditis (HT) is a prevalent autoimmune disease. We investigated the relationship of peripheral blood long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) and microRNA (miR)-146a levels with Th17/Treg-related cytokines in HT patients and their clinical significance. Correlations of PVT1 and miR-146a with Th17/Treg-related cytokines were analyzed, and its clinical value in diagnosing HT was assessed. Results showed reduced lncRNA-PVT1 and interleukin (IL)-10 levels and increased miR-146a and IL-17 levels in HT patients. lncRNA-PVT1 negatively interrelated with miR-146a, IL-17, IL-23 and IL-6, and positively interrelated with IL-10; miR-146a positively correlated with IL-17, IL-23 and IL-6, but negatively correlated with IL-10 in HT patients. The area under the curve (AUC) of lncRNA-PVT1 and miR-146a levels for diagnosing HT were 0.822 and 0.844, respectively (sensitivity 88.73% and 86.62%, specificity 67.02% and 69.15%, cut-off values 0.76 and 2.73), with their combined detections yielding a higher AUC. Patients with poorly expressed lncRNA-PVT1 and highly expressed miR-146a had elevated HT incidence. lncRNA-PVT1 and miR-146a levels were also found to be an independent influencing factor for HT occurrence. Our findings suggest that HT patients have low peripheral blood lncRNA-PVT1 expression and high miR-146a expression. lncRNA-PVT1 and miR-146a level changes were correlated with Th17/Treg cytokine imbalance and could be a potential diagnostic tool and independent influencing factor for HT.

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The relationship of peripheral blood lncRNA-PVT1 and miR-146a levels with Th17/Treg cytokines in patients with Hashimoto’s thyroiditis and their clinical significance

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Published

06-09-2024

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Research article

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1.
The relationship of peripheral blood lncRNA-PVT1 and miR-146a levels with Th17/Treg cytokines in patients with Hashimoto’s thyroiditis and their clinical significance. Biomol Biomed [Internet]. 2024 Sep. 6 [cited 2024 Oct. 9];24(5):1170–1177. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/10237