Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia

  • Demet Laflı Tunay Department of Anesthesiology, Cukurova University Faculty of Medicine, Adana, Turkey https://orcid.org/0000-0002-7984-1800
  • Murat Türkeün Ilgınel Department of Anesthesiology, Cukurova University Faculty of Medicine, Adana, Turkey
  • Hakkı Ünlügenç Department of Anesthesiology, Cukurova University Faculty of Medicine, Adana, Turkey
  • Merthan Tunay Ministry of Health, Provincial Health Directorate, Adana, Turkey https://orcid.org/0000-0003-2838-5531
  • Feride Karacaer Department of Anesthesiology, Cukurova University Faculty of Medicine, Adana, Turkey
  • Ebru Biricik Department of Anesthesiology, Cukurova University Faculty of Medicine, Adana, Turkey https://orcid.org/0000-0002-3355-198X
Keywords: Melatonin, morphine consumption, postoperative analgesia, vitamin C

Abstract

The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesic effects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of single preoperative dose of oral melatonin or vitamin C administration on postoperative analgesia. In this study, we recruited 165 adult patients undergoing elective major abdominal surgery under general anesthesia. Patients were randomly divided into three equal (n = 55) groups. One hour before surgery, patients received orally melatonin (6 mg) in group M, vitamin C (2 g) in group C, or a placebo tablet in group P. Pain, sedation, patient satisfaction, total morphine consumption from a patient-controlled analgesia device, supplemental analgesic requirement, and the incidence of nausea and vomiting were recorded throughout 24 h after surgery. The mean pain score and total morphine consumption were found significantly lower in both M and C groups compared with group P (p < 0.001). There were no significant differences between group M and C with respect to pain scores (p = 0.117) and total morphine consumption (p = 0.090). Patients requested less supplemental analgesic and experienced less nausea and vomiting in groups M and C compared with group P. In conclusion, preoperative oral administration of 6 mg melatonin or 2 g vitamin C led to a reduction in pain scores, total morphine consumption, supplemental analgesic requirement, and the incidence of nausea and vomiting compared with placebo.

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Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia
Published
2019-08-30
How to Cite
1.
Laflı Tunay D, Türkeün Ilgınel M, Ünlügenç H, Tunay M, Karacaer F, Biricik E. Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia. Bosn J of Basic Med Sci [Internet]. 2019Aug.30 [cited 2019Oct.22];00. Available from: http://bjbms.org/ojs/index.php/bjbms/article/view/4379
Section
Translational and Clinical Research