Characteristics and prognostic factors of age-stratified high-grade intracranial glioma patients: A population-based analysis

  • Yun Sun Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Zhi-Yong Xiong Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Peng-Fei Yan Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Liang-Lei Jiang Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Chuan-Sheng Nie Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Xuan Wang Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Keywords: prognosis, surveillance, Epidemiology and End Results (SEER) Program, SEER, glioma

Abstract

We evaluated characteristics and different prognostic factors for survival in age-stratified high-grade glioma in a U.S. cohort. Eligible patients were identified in the Surveillance, Epidemiology, and End Results (SEER) registries and stratified into 3 age groups: 20–39 years old (1,043 patients), 40–59 years old (4,503 patients), and >60 years old (5,045 patients). Overall and cancer-related survival data were obtained. Cox models were built to analyze the outcomes and risk factors. It showed that race was a prognostic factor for survival in patients 40 to 59 years old and in patients ≥60 years old. Partial resection was associated with lower overall survival and cause-specific survival in all age groups (overall survival: 20–39 yr: HR = 6.41; 40–59 yr: HR = 4.84; >60 yr: HR = 5.06; cause-specific survival: 20–39 yr: HR = 5.87; 40–59 yr: HR = 4.01; >60 yr: HR = 3.36). The study highlights that, while some prognostic factors are universal, others are age-dependent. The effectiveness of treatment approaches differs for patients in different age groups. Results of this study may help to develop personalized treatment protocols for glioma patients of different ages.

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Characteristics and prognostic factors of age-stratified high-grade intracranial glioma patients: A population-based analysis
Published
2019-11-08
How to Cite
1.
Sun Y, Xiong Z-Y, Yan P-F, Jiang L-L, Nie C-S, Wang X. Characteristics and prognostic factors of age-stratified high-grade intracranial glioma patients: A population-based analysis. Bosn J of Basic Med Sci [Internet]. 2019Nov.8 [cited 2019Nov.18];19(4):375-83. Available from: http://bjbms.org/ojs/index.php/bjbms/article/view/4213
Section
Translational and Clinical Research