Intervertebral disc tissue engineering: A brief review

  • Janja Stergar Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Laboratory of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, University of Maribor, Maribor, Slovenia
  • Lidija Gradisnik Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Alma Mater Europaea – European Center Maribor (AMEU-ECM), Maribor, Slovenia
  • Tomaz Velnar Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Alma Mater Europaea – European Center Maribor (AMEU-ECM), Maribor, Slovenia Department of Neurosurgery, University Medical Centre Ljubljana, Ljubljana, Slovenia
  • Uros Maver Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Department of Pharmacology, Faculty of Medicine, University of Maribor, Maribor, Slovenia https://orcid.org/0000-0002-2237-3786
Keywords: Intervertebral disc, IVD, cell-based therapies, biomaterials, scaffolds, tissue engineering, IVD degeneration, IDD

Abstract

Intervertebral disc (IVD) degeneration (IDD) is associated with low back pain and significantly affects the patient’s quality of life. Degeneration of the IVD alters disk height and the mechanics of the spine, leading to chronic segmental spinal instability. The pathophysiology of IVD disease is still not well understood. Current therapies for IDD include conservative and invasive approaches, but none of those treatments are able to restore the disc structure and function. Recently, tissue engineering techniques emerged as a possible approach to treat IDD, by replacing a damaged IVD with scaffolds and appropriate cells. Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered the development of tissue engineering therapies. In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed.

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Author Biographies

Tomaz Velnar, Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Alma Mater Europaea – European Center Maribor (AMEU-ECM), Maribor, Slovenia Department of Neurosurgery, University Medical Centre Ljubljana, Ljubljana, Slovenia
Department of Neurosurgery
Uros Maver, Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia Department of Pharmacology, Faculty of Medicine, University of Maribor, Maribor, Slovenia
Department of Pharmacology
Intervertebral disc tissue engineering: A brief review
Published
2019-05-20
How to Cite
1.
Stergar J, Gradisnik L, Velnar T, Maver U. Intervertebral disc tissue engineering: A brief review. Bosn J of Basic Med Sci [Internet]. 2019May20 [cited 2019Nov.13];19(2):130-7. Available from: http://bjbms.org/ojs/index.php/bjbms/article/view/3778
Section
Reviews