The effect of continuous jejunal interposition on gastrointestinal hormones after distal gastrectomy

  • Zhen-Ye Lv Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Zai-Yuan Ye Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Qin-Shu Shao Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Wei Zhang Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Qin Zhang Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Yuan-Shui Sun Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Shu-Guang Li Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Yuan-Yu Wang Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
  • Ji Xu Department of Gastrointestinal Surgery, Zhejiang Provincal People’s Hospital
Keywords: distal gastrectomy, continuous jejunal interpositionon, serum gastrin plasma motilin, sholecystokinin

Abstract

The objective of our study was to determine the effect of continuous jejunal interposition on gastrointestinal hormones after distal gastrectomy, and lay a foundation for surgical management.

Distal subtotal gastrectomy experimental model were established on 24 adult Beagle dogs. Digestive tract reconstruction of the dogs was randomly divided into continuous jejunal interposition group, Billroth II anastomosis group and isolated jejunum interposition group. The content of serum gastrin, plasma motilin and cholecystokinin after different digestive tract reconstructions was detected and compared by enzyme-linked immunosorbent assay

In the dogs which received continuous jejunal interposition, postoperative serum gastrin level was significantly lower than before surgery either in fasting or postprandial state (all p<0.05). The serum gastrin level of continuous jejunal interposition group was significantly higher than the other groups in postprandial state (all p<0.05), and was significantly higher than Billroth II -type anastomosis group in fasting state (p<0.05). Furthermore, the postoperative plasma motilin and cholecystokinin levels were significantly higher than before surgery either in fasting or postprandial in dogs received continuous jejunal interposition (all p<0.05). The postoperative plasma motilin level of continuous jejunal interposition group was significantly higher than the other groups in postprandial state (all p<0.05), and was significantly higher than Billroth II -type anastomosis group in fasting state (p<0.05). However, the postoperative cholecystokinin level of continuous jejunal interposition group was significantly lower than the other groups (allp p<0.05).

Continuous jejunal interposition after distal gastrectomy could maintain the postoperative plasma motilin and serum gastrin in a relatively high level, while cholecystokinin in a low level.

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The effect of continuous jejunal interposition on gastrointestinal hormones after distal gastrectomy
Published
2012-02-20
How to Cite
1.
Lv Z-Y, Ye Z-Y, Shao Q-S, Zhang W, Zhang Q, Sun Y-S, Li S-G, Wang Y-Y, Xu J. The effect of continuous jejunal interposition on gastrointestinal hormones after distal gastrectomy. Bosn J of Basic Med Sci [Internet]. 2012Feb.20 [cited 2020Aug.14];12(1):10-4. Available from: http://bjbms.org/ojs/index.php/bjbms/article/view/2524
Section
Short Communication