Follicular morphological characteristics may be associated with invasion in follicular thyroid neoplasms with papillary-like nuclear features

Authors

  • Nuray Can Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Mehmet Celik Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Yavuz Atakan Sezer Department of General Surgery, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Filiz Ozyilmaz Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Semra Ayturk Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Ebru Tastekin Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Necdet Sut Department of Biostatistics, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Hakan Gurkan Department of Medical Genetics, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Funda Ustun Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Buket Yilmaz Bulbul Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Sibel Guldiken Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Fulya Oz Puyan Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey

DOI:

https://doi.org/10.17305/bjbms.2017.2039

Keywords:

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features, NIFTP, EFVPTC, histomorphological features, follicular variant of papillary thyroid carcinoma, FVPTC, NRAS, BRAF, mutation

Abstract

The newly proposed nomenclature and diagnostic criteria for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), could improve the consistency and accuracy of diagnosing this entity. Diagnosis of NIFTP requires evaluation of the complete tumor border or capsule. The presence of tumor invasion in follicular thyroid neoplasms with papillary-like nuclear features has been recently discussed by many authors. In this study, we examined the predictive value and association of follicular morphological characteristics with the tumor invasion. In addition, we analyzed the association between tumor encapsulation and molecular profile in EFVPTC/NIFTP cases. A total of 106 cases of FVPTC were included in the study. The tumors were grouped based on the presence of tumor capsule and characteristics of tumor border, as 1) completely encapsulated tumors without invasion, 2) encapsulated tumors with invasion, 3) infiltrative tumors without a capsule. Clinicopathological features, histomorphological features [nuclear criteria, minor diagnostic features, follicles oriented perpendicular to tumor border/capsule (FOPBC)] and molecular alterations in BRAF, NRAS, and KRAS genes were evaluated. FOPBC were significantly more frequently seen in encapsulated tumors with invasion (p = 0.008). The nuclear features were not associated with the presence of encapsulation and characteristics of tumor border. BRAF mutation was more frequent in infiltrative tumors, while NRAS mutation was more frequent in encapsulated tumors, but the results were not statistically significant (p = 0.917). In conclusion, FOPBC histomorphological feature may be associated with tumor invasion in EFVPTC/NIFTP. Additionally, BRAF/KRAS/NRAS mutation analysis may prevent inadequate treatment in these patients.

Author Biographies

  • Nuray Can, Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Pathology
  • Mehmet Celik, Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Internal Medicine
  • Yavuz Atakan Sezer, Department of General Surgery, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of General Surgery
  • Filiz Ozyilmaz, Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Pathology
  • Semra Ayturk, Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Internal Medicine
  • Ebru Tastekin, Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Pathology
  • Necdet Sut, Department of Biostatistics, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Biostatistics
  • Hakan Gurkan, Department of Medical Genetics, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Medical Genetics
  • Funda Ustun, Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Nuclear Medicine
  • Buket Yilmaz Bulbul, Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Internal Medicine
  • Sibel Guldiken, Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Internal Medicine
  • Fulya Oz Puyan, Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Department of Pathology

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Follicular morphological characteristics may be associated with invasion in follicular thyroid neoplasms with papillary-like nuclear features

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20-08-2017

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1.
Follicular morphological characteristics may be associated with invasion in follicular thyroid neoplasms with papillary-like nuclear features. Biomol Biomed [Internet]. 2017 Aug. 20 [cited 2024 Mar. 29];17(3):211-20. Available from: https://bjbms.org/ojs/index.php/bjbms/article/view/2039